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Cantargia AB (publ) meddelar idag att nya prekliniska data runt antikroppen CAN04 (nidanilimab) kommer presenteras på den vetenskapliga konferensen 

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"Dessa data är mycket lovande för utvecklingen av CAN04. De visar att CAN04 kan kombineras på ett säkert sätt med cellgifter för att förstärka 

Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet. Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany. CAN04 is in clinical development for cancer therapy and targets interleukin 1 receptor accessory protein, IL1RAP, positive single agent clinical data was recently presented at ESMO. The new results give further support for an important role of CAN04 also in combination with chemotherapy and provide new insights into the advantages of targeting IL1RAP as a treatment strategy in non-small cell ”With most new data at ASCO being selected for poster presentations, an oral presentation at ASCO annual meeting is clearly a milestone for Cantargia leading to increased exposure and attention of the CAN04 project”, Göran Forsberg, Cantargia’s CEO says. For further information, please contact Göran Forsberg, CEO Telephone: +46 (0)46 Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s.k.

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Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet. Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany. CAN04 is in clinical development for cancer therapy and targets interleukin 1 receptor accessory protein, IL1RAP, positive single agent clinical data was recently presented at ESMO. The new results give further support for an important role of CAN04 also in combination with chemotherapy and provide new insights into the advantages of targeting IL1RAP as a treatment strategy in non-small cell ”With most new data at ASCO being selected for poster presentations, an oral presentation at ASCO annual meeting is clearly a milestone for Cantargia leading to increased exposure and attention of the CAN04 project”, Göran Forsberg, Cantargia’s CEO says.

Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany.

Enhanced effects of CAN04 was also observed in combination with two commonly used platinum doublets, cis/gem and oxaliplatin/5-FU. CAN04 studeras i en öppen klinisk fas I/IIa-prövning, CANFOUR, som undersöker första linjens kemoterapikombination med två olika standardregimer hos 31 patienter med NSCLC (gemcitabin/cisplatin) och 31 patienter med PDAC (gemcitabin/nab-paclitaxel), samt monoterapi hos patienter i sen fas (www.clinicaltrials.gov). During 2019, Cantargia also reported positive preclinical data on the combination of CAN04 and platinum-based compounds. The new results presented at AACR show both parts of the IL-1 system to be upregulated in the tumor tissue in mice after treatment with the chemotherapy doublet cisplatin/gemcitabine (cis/gem) which is clinically used in the CANFOUR study.

CAN04 is however an ADCC-enhanced antibody lacking fucose produced by the Potelligent ® technology. The new results show that similar modifications can be introduced in mouse surrogate antibodies. Afucosylation of murine antibodies leads to enhanced binding to receptors present on immune cells, a stronger immune-cell mediated killing and a more pronounced antitumor effect.

11 mars  Cantargia uppger att nya data tyder på att utvecklingsprojektet CAN04 uppvisar en kraftig antitumöraktivitet på tumörer från lever, matstrupe och huvud-hals  Cantargia AB (publ) meddelar idag att nya prekliniska data runt antikroppen CAN04 (nidanilimab) kommer presenteras på den vetenskapliga konferensen  Prekliniska data visar att CAN04 ökar effekten av cellgifter. CAN04 studeras i en fas I/IIa klinisk studie, CANFOUR, som undersöker  Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting januari 13, 2021; Truly Labs part of Biobarrier research profile at Malmö  Upload, livestream, and create your own videos, all in HD. Join Vimeo. Log in  Ny data öppnar för fas 3-studie nästa år Cantargia meddelade i dagarna att bolaget ska Vi tror att den trend som CAN04 visade upp i de preliminära data som  "Dessa data är mycket lovande för utvecklingen av CAN04.

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Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 % av patienterna med urinblåsecancer. In addition to exploring CAN04 in the context of cancer progression after pembrolizumab therapy, the data generated will be used to potentially expand the use of CAN04. The results from this trial, together with the data generated on CAN04 in combination with platinum-based chemotherapy, will be the basis for studies of CAN04 in combination with pembrolizumab and chemotherapy. Uppdaterade data kommer redovisas vid presentationen den 2 juni, 2019.

Preclinical data show that CAN04 Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov).
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Cantargia presents new preclinical data on CAN04 at the 2020 AACR Annual Meeting. Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy. CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different chemotherapy regimes. Cantargia AB (“Cantargia”) today presented new preclinical data

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Apr 3, 2018 Note: Male share of total parental leave is from 2015 and female leadership data is from 2016. 1Leadership positions defined as legislators,  10 mar 2021 Cantargia's lead asset CAN04 (anti-IL1RAP) is a potential competitor. While we acknowledge that Novartis's data has created negative  Mar 22, 2021 Data that is produced by monitoring probes is stored in the UIM database, in tables named raw data tables (table prefix is RN_).

Cantargia Presents New Preclinical Data on CAN04 at the 2020 AACR Annual Meeting. PRESS RELEASE PR Newswire . Jun. 22, 2020, 03:13 PM "Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens. Det bekräftar Cantargias engagemang att förse patienter som har livshotande sjukdomar med nya, innovativa och säkra terapeutiska möjligheter", sa Göran Forsberg, VD på Cantargia.